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In vivo functional brain mapping in a conditional mouse

In vivo functional brain mapping in a conditional mouse model of human tauopathy tau p301l reveals reduced neural activity in memory formation structures Pablo D Perez , 1 Gabrielle Hall , 1 Tetsuya Kimura , 3 Yan Ren , 2 Rachel M Bailey , 2 Jada Lewis , 2 Marcelo Febo , 1 and Naruhiko Sahara 2

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infoldings observed in the sciatic nerve Veiga et al. Neurosci. Lett. 402:150 153, 2006 . Finally, treatment with a ligand of translocator protein 18 kDa TSPO , such as Ro5 4864, was able to reduce the severity of diabetic neuropathy Giatti et al., USA. 3. Dept. of Physiology, UTHSCSA, San Antonio, Texas, USA. Hippocampus plays a central

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In vivo functional brain mapping in a conditional mouse model of human tauopathy tau P301L reveals reduced neural activity in memory formation structures

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In vivo functional brain mapping in a conditional mouse

In order to map basal brain activity in rTg4150 mice n=5; 5.5 6.3 M and control nonTg littermates n=5; 5.5 6.3 M , MnCl 2 was administered at a dose of 70 mg/kg, i.p. 24 hrs prior to MRI scanning. Animals were handled every two weeks and acclimatized to the investigator providing the injections.

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In vivo functional brain mapping in a conditional mouse

Feb 04, 2013 & 0183;& 32;Tauopathies are characterized by intracellular deposition of the microtubule associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally ees mutant human tau protein in various forebrain areas under the Tet off eion system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral

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3 Layers BT 32610 2006 mask in USA